期刊
NEUROCHEMISTRY INTERNATIONAL
卷 51, 期 2-4, 页码 233-236出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuint.2007.06.003
关键词
D-Cycloserine; glycine; in vivo microdialysis; medial frontal cortex; D-Serine; L-serine
A partial agonist of the N-methyl-D-aspartate (NMDA) receptor, D-cycloserine, acting at its glycine modulatory site, ameliorates the neuropsychiatric symptoms that are mimicked by NMDA antagonists and include cognitive disturbances, antipsychotic-resistant schizophrenic symptoms and cerebellar ataxia. To obtain a further insight into the mechanisms of the therapeutic efficacies Of D-cycloserine, we investigated the effects of the systemic administration of D-Cycloserine on the extracellular contents of an endogenous NMDA co-agonist, D-serine, in the medial frontal cortex of the rat using an in vivo dialysis technique. An acute intraperitoneal injection Of D-cycloserine (50 and 100 mg/kg) caused an increase in extracellular concentrations of D-serine without significant effects on those Of L-serine, glycine, L-glutamate, L-aspartate, L-glutamine, L-asparagine, L-alanine, L-threonin and taurine in the medial frontal cortex. The selective increase in the extracellular D-serine contents may, at least partially, be associated with the facilitating effects Of D-cycloserine on the NMDA receptor functions in addition to its direct stimulation of the NMDA receptor glycine site. (C) 2007 Elsevier Ltd. All fights reserved.
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