期刊
JOURNAL OF BIOMEDICAL OPTICS
卷 12, 期 4, 页码 -出版社
SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
DOI: 10.1117/1.2756102
关键词
nonlinear optical microscopy; endoscopy; photonic crystal fiber; microelectromechanical system (MEMS) mirror; three-dimensional (3-D) tissue imaging
The development of miniaturized nonlinear optical microscopy or endoscopy is essential to complement the current imaging modalities for diagnosis and monitoring of cancers. We report on a nonlinear optical endoscope based on a double-clad photonic crystal fiber and a two-dimensional (2-D) microelectromechanical system mirror, enabling the three-dimensional (3-D) nonlinear optical imaging through in vitro gastrointestinal tract tissue and human breast cancer tissue with a penetration depth of approximately 100 mu m and axial resolution of 10 mu m. The 3-D high-resolution and high-sensitive imaging ability of the nonlinear optical endoscope facilitates the visualization of 3-D morphologic and cell nuclei arrangement within tissue, and therefore will be important for histopathologic interpretation without the need of tissue excision. (C) 2007 Society of Photo-Optical Instrumentation Engineers.
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