期刊
HUMAN MOLECULAR GENETICS
卷 16, 期 13, 页码 1569-1577出版社
OXFORD UNIV PRESS
DOI: 10.1093/hmg/ddm105
关键词
-
资金
- NIGMS NIH HHS [GM60518, GM069985, R01 GM060518] Funding Source: Medline
LINE-1 elements comprise approximately 17% of human DNA and their mobility continues to impact genome evolution. However, little is known about the types of non-transformed cells that can support LINE-1 retrotransposition. Here, we show that human embryonic stem cells express endogenous LINE-1 elements and can accommodate LINE-1 retrotransposition in vitro. The resultant retrotransposition events can occur into genes and can result in the concomitant deletion of genomic DNA at the target site. Thus, these data suggest that LINE-1 retrotransposition events may occur during early stages of human development.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据