期刊
ARCHIVES OF ORAL BIOLOGY
卷 52, 期 7, 页码 684-690出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.archoralbio.2006.12.010
关键词
MEPE; mechanical loading; osteocytes; tooth movement
资金
- NIAMS NIH HHS [AR46798, P01 AR046798] Funding Source: Medline
- NIDCR NIH HHS [R03 DE016949, R03 DE16949] Funding Source: Medline
MEPE and DMPI may play a role in mineralisation and demineralisation within the osteocyte microenvironment. our earlier studies showed that DMP1 is mechanically responsive [Gluhak-Heinrich J, Ye L, Bonewald LF, Feng JQ, MacDougall M, Harris SE, et al. Mechanical loading stimulates dentin matrix protein 1 (DMP1) in osteocytes in vivo. J Bone Min Res 2003; 18(5):807-17]. Objectives: To examine the effect of mechanical loading on the expression of MEPE using mouse tooth movement model, and compare this effect to that on DMP1. Methods: In situ hybridisation and immunohistochemistry was performed on 38 treated and 38 control bone sites loaded 6-72 h. ImageJ was used for quantification of mRNA expression in osteocytes. Results: Alveolar osteocytes showed high basal level of MEPE that decreased during the first day of loading, followed by 2.8-fold stimulation at day 3, and returning to a control level by day 7. Conclusion: The osteocyte specific mechanical stimulation of MEPE was delayed and different, compared to that of DMP1. This suggests a distinct role of MEPE and DMP1 in the response of osteocytes to mechanical loading in vivo. (c) 2006 Elsevier Ltd. All rights reserved.
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