期刊
NATURE IMMUNOLOGY
卷 8, 期 7, 页码 743-752出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ni1469
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- Intramural NIH HHS Funding Source: Medline
T lymphocytes lacking the lymph node-homing receptors L-selectin and CCR7 do not migrate to lymph nodes in the steady state. Instead, we found here that lymph nodes draining sites of mature dendritic cells or adjuvant inoculation recruited L-selectin- negative CCR7(-) effector and memory CD8(+) T cells. This recruitment required CXCR3 expression on T cells and occurred through high endothelial venules in concert with lumenal expression of the CXCR3 ligand CXCL9. In reactive lymph nodes, recruited T cells established stable interactions with and killed antigen-bearing dendritic cells, limiting the ability of these dendritic cells to activate naive CD4(+) and CD8(+) T cells. The inducible recruitment of blood-borne effector and memory T cells to lymph nodes may represent a mechanism for terminating primary and limiting secondary immune responses.
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