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Borrowing hydrogen in the activation of alcohols

期刊

ADVANCED SYNTHESIS & CATALYSIS
卷 349, 期 10, 页码 1555-1575

出版社

WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.200600638

关键词

alcohols; amines; catalysis; transfer hydrogenation; transition metals

资金

  1. Engineering and Physical Sciences Research Council [GR/S87355/01] Funding Source: researchfish

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Alcohols can be temporarily converted into carbonyl compounds by the metal-catalysed removal of hydrogen. The carbonyl compounds are reactive in a wider range of transformations than the precursor alcohols and can react in situ to give imines, alkenes, and alpha-functionalised carbonyl compounds. The metal catalyst, which had borrowed the hydrogen, then returns it to the transformed carbonyl compound, leading to an overall process in which alcohols can be converted into amines, compounds containing C-C bonds and beta-functionalised alcohols.

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