期刊
GENES BRAIN AND BEHAVIOR
卷 6, 期 5, 页码 491-496出版社
WILEY
DOI: 10.1111/j.1601-183X.2007.00316.x
关键词
5-HT2CR; amygdala; anxiety; BNST; CeA; corticotropin-releasing hormone; knockout; serotonin
资金
- NIDDK NIH HHS [R01DK065171] Funding Source: Medline
- NIMH NIH HHS [R01MH61624] Funding Source: Medline
Central serotonin (5-hydroxytryptamine, 5-HT) systems have been implicated in the pathophysiology and treatment of anxiety disorders, which are among the world's most prevalent psychiatric conditions. Here, we report that the 5-HT2C receptor (5-HT2CR) subtype is critically involved in regulating behaviors characteristic of anxiety using male 5-HT2CR knockout (KO) mice. Specific neural substrates underlying the 5-HT2CR KO anxiolytic phenotype were investigated, and we report that 5-HT2CR KO mice display a selective blunting of extended amygdala corticotropin-releasing hormone neuronal activation in response to anxiety stimuli. These findings illustrate a mechanism through which 5-HT(2C)Rs affect anxiety-related behavior and provide insight into the neural circuitry mediating the complex psychological process of anxiety.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据