期刊
BRITISH JOURNAL OF HAEMATOLOGY
卷 138, 期 1, 页码 68-71出版社
BLACKWELL PUBLISHING
DOI: 10.1111/j.1365-2141.2007.06612.x
关键词
mast cells; non-Hodgkin lymphoma; prognostic factors
类别
Previous studies indicate that the inflammatory response in diffuse large B-cell lymphomas (DLBCL) is important for the clinical outcome. Mast cells are key regulators in this response; we investigated whether the number of tryptase-positive mast cells is correlated with clinical outcome. Patients with many mast cells had a significantly better event-free survival (EFS) compared to those with few mast cells (P < 0.03 in both germinal centre (GC) and non-GC DLBCL. This supports the idea that the infiltration of mast cells is a reflection of the host inflammatory response and is related to a favourable outcome.
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