期刊
NATURE IMMUNOLOGY
卷 8, 期 7, 页码 762-771出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ni1477
关键词
-
类别
资金
- NIAID NIH HHS [R01 AI067467-01A1, AI 39816, AI55638, R01 AI067467] Funding Source: Medline
Because functional analysis of Fc receptors (FcRs) relies heavily on mouse models, the identification of another Fc gamma receptor is particularly noteworthy. We demonstrate that Fc gamma RIV, identified here as the mouse ortholog of primate Fc gamma RIII, required association of the FcR gamma-chain for optimal expression and function on myeloid cells; its signaling potential was also enhanced by a cytoplasmic 'YEEP' motif that was able to recruit the adaptor molecule Crk-L and phosphatidylinositol-3-OH kinase. Unexpectedly, Fc gamma RIV 'preferentially' bound immunoglobulin E antibodies of the 'b' allotype (IgE(b)) as well as IgG2a and IgG2b antibodies. Ligation of Fc gamma RIV by antigen-IgE(b) immune complexes promoted macrophage-mediated phagocytosis, presentation of antigen to T cells, production of proinflammatory cytokines and the late phase of cutaneous allergic reactions. IgE(b) antibody-mediated modification of macrophage responses may therefore influence mouse asthma models and strain-dependent differences in parasite susceptibility.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据