期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 64, 期 14, 页码 1841-1852出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-007-7034-x
关键词
aminoglycoside antibiotics; cystic fibrosis; drug discovery; muscular dystrophy; ribosome; RNA
资金
- NIAID NIH HHS [AI 72012] Funding Source: Medline
Aminoglycoside antibiotics kill bacteria by binding to the ribosomal decoding site and reducing fidelity of protein synthesis. Since the discovery of these natural products over 50 years ago, aminoglycosides have provided a mainstay of antibacterial therapy of serious Gram-negative infections. In recent years, aminoglycosides have become important tools to study molecular recognition of ribonucleic acid (RNA). In an ingenious exploitation of the aminoglycosides' mechanism of action, it has been speculated that drug-induced readthrough of premature stop codons in mutated messenger RNAs might be used to treat patients suffering from certain heritable genetic disorders.
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