期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 51, 期 7, 页码 2631-2635出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.01492-06
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资金
- BBSRC [BB/D010632/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/D010632/1] Funding Source: researchfish
- Biotechnology and Biological Sciences Research Council [BB/D010632/1] Funding Source: Medline
Type III secretion systems (T3SS) are conserved in many pathogenic gram-negative bacteria. Small molecules that specifically target T3SS in Yersinia and Chlamydia spp. have recently been identified. Here we show that two such compounds inhibit Salmonella T3SS-1, preventing secretion of T3SS-1 effectors, invasion of cultured epithelial cells, and enteritis in vivo.
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