期刊
ELECTROPHORESIS
卷 28, 期 14, 页码 2424-2429出版社
WILEY
DOI: 10.1002/elps.200600559
关键词
CZE; iron dextran; iron gluconate; iron saccharate; labile iron
The present study describes the application of CZE to investigate the portion of labile iron in the following parenteral formulations: iron gluconate, iron saccharate, and iron dextran. Labile iron was detected as Fe(III)-chelate of EDTA at 246 rim. When EDTA was incubated with the formulations before electrophoresis, labile iron, or chelatable iron, respectively, was detected in all formulations, mostly in iron gluconate and iron saccharate. It was observed that the amount of iron released is time- and pH-dependent. In contrast, when EDTA was separately injected before the formulation sharp peaks of the Fe(III)-chelate were detected only after injection of iron gluconate. This type of labile iron can be described as electrophoretically free iron. CE provides thus a new method to characterize potential toxic, labile iron in parenteral iron formulations.
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