期刊
ANALYTICAL CHEMISTRY
卷 84, 期 3, 页码 1240-1242出版社
AMER CHEMICAL SOC
DOI: 10.1021/ac300034r
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资金
- Institute for Collaborative Biotechnologies from the U.S. Army Research Office [W911NF-09-D-0001]
- National Cancer Institute [R01CA119402]
We present a general method to quantify coatings on microparticle surfaces based on the additional mass. Particle buoyant mass is determined in a solution with a density that is nearly equivalent to that of the core particle, reducing the magnitude and uncertainty of the measurement. Under these conditions, added material with a different density than that of the core is a larger fraction of the total buoyant mass of the coated particle. This method can resolve a buoyant mass difference between uncoated and coated particles of similar to 1 fg. For the protein layer on the 3 mu m polystyrene spheres measured herein, this is equivalent to 1/10th of a full layer.
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