期刊
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
卷 39, 期 7, 页码 1131-1138出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1249/mss.0b013e318053e7a2
关键词
fitness; inflammation; adolescence; bone mineralization; body composition; growth mediators
资金
- NCRR NIH HHS [M01 RR00827] Funding Source: Medline
- NHLBI NIH HHS [R01-HL080947] Funding Source: Medline
- NICHD NIH HHS [HD-37746, HD048721] Funding Source: Medline
Purpose: Physical inactivity is deleterious to health, but it has been difficult to determine the extent to which these effects are attributable to abnormal body composition or to factors related to physical activity alone. To begin to gauge independent effects of physical activity on health risk, we matched by BMI two groups of normal-weight adolescent females, one physically active (all participants in high school sports), and one sedentary. Methods: Thirty-seven sedentary and 37 physically active adolescent females (mean 15.5 yr) were matched for age and BMI percentile (mean = 58.8). Comparisons included fitness, body composition and bone mineralization (by DEXA), circulating inflammatory cytokines, growth factors, bone-turnover markers, leptin, and adiponectin. Results: Compared with the normal-weight sedentary girls, active girls had significantly (P < 0.05) higher fitness level (peak VO2 35.5 +/- 5.2 vs 24.4 +/- 4.1 mL center dot kg(-1)center dot min(-1)), lean body mass (43.2 +/- 4.4 vs 38.7 +/- 3.6 kg), bone mineralization (spinal BMD z-scores 0.04 +/- 0.88 vs -0.41 +/- 0.85), and lower percent body fat (25.4 +/- 04.6 vs 29.7 +/- 03.7%). Additionally, active girls had lower inflammatory cytokines levels (e.g., TNF-alpha 1.7 +/- 1.3 vs 2.6 +/- 2.2 pg center dot mL(-1)), and leptin (17.4 +/- 11.2 vs 24.7 +/- 14.7 ng center dot mL(-1)), and higher bone-turnover markers (e.g. osteocalcin 12.6 +/- 7.6 vs 7.8 +/- 3.0 U center dot L-1), IGFBP-3 (6416 +/- 21280 vs 4247 +/- 1082 ng center dot rnL(-1)), and adiponectin levels (11919 +/- 3935 vs 9305 +/- 2843 ng center dot mL(-1)). Conclusion: The normal-weight, physically active group was fitter and had greater lean body mass, stronger bones, and lower levels of inflammatory markers than did the normal-weight, sedentary group. in adolescent girls, the choice of a lifestyle involving high school sports is characterized by a circulating mediator and body composition pattern that, if sustained, is associated with generally lower long-term risk of cardiovascular disease and osteoporosis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据