期刊
MITOCHONDRION
卷 7, 期 4, 页码 279-283出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.mito.2007.04.003
关键词
vagus nerve stimulation; myoclonic seizures; mitochondrial electron transport chain disorder; children; epilepsy
We retrospectively investigated outcome data for vagus nerve stimulation (VNS) in children less than 12 years of age with intractable seizures and mitochondrial disease. Five children with a mitochondrial disease, due to electron transport chain deficiency, were studied. Information was collected from clinic visits prior to, and subsequent to, VNS implantation. Data were collected by type and frequency of seizures, encephalogram and neuroimaging findings, and medication history. Four of the children had predominantly myoclonic seizures, while the other child had focal seizures with secondary generalization and myoclonic seizures. All five children did not have significant reduction in seizure frequency with VNS. VNS may not be an effective method to control myoclonic seizures in children with electron transport chain disorders. (c) 2007 Elsevier B.V. on behalf of Mitochondria Research Society.
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