期刊
JOURNAL OF ENDODONTICS
卷 33, 期 7, 页码 796-799出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.joen.2007.01.021
关键词
diagnostic instrument; irreversible pulpitis; local anesthesia; mechanical allodynia; periradicular periodontitis
资金
- NIDA NIH HHS [P01 DA16719] Funding Source: Medline
- NIDCR NIH HHS [K23 DE14864] Funding Source: Medline
- NINDS NIH HHS [R01 NS45186] Funding Source: Medline
An essential feature of symptomatic periradicular inflammation is mechanical allodynia, defined as reduced mechanical pain thresholds. A previous study evaluating a new digital force transducer showed that it reliably measures mechanical pain thresholds of teeth with normal periradicular tissues. In this study, we tested the hypothesis that the force transducer quantitatively measures mechanical allodynia in teeth with acute periradicular periodontitis (APP) and detects the effects of local anesthetic injection. Mechanical pain thresholds were measured in patients (n = 30) with irreversible pulpitis (IP) and APP and compared with their contralateral teeth. The results show that the mechanical pain thresholds of teeth with IP and APP were reduced by 77% compared with contralateral control teeth. The administration of local anesthesia reversed the mechanical allodynia by 62%, and significant sex-specific effects were observed. In addition, the normal teeth contralateral to the symptomatic teeth had lower mechanical thresholds than those observed in healthy volunteers, suggesting that central sensitization occurs during this type of odontalgia. Thus, we show that the mechanical pain thresholds are significantly reduced in teeth with IP and APP and that the force transducer has potential application as a diagnostic aid in measuring mechanical allodynia and as an outcome measure in endodontic clinical trials such as pharmacologic studies and mechanistic research.
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