期刊
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
卷 18, 期 7, 页码 2014-2020出版社
AMER SOC NEPHROLOGY
DOI: 10.1681/ASN.2007040453
关键词
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资金
- NIDDK NIH HHS [R01 DK066408-03, DK066408, R01 DK066408] Funding Source: Medline
The structure of a mammalian kidney is parsed into large collections of polarized nephrons, and each segment is home to a diverse community of cells that specialize in renal endocrine and excretory functions. Early developmental lengthening and diversification of nephron segments along a proximal-distal axis initiate all subsequent facets of tubular growth and function. Morphogenic cues and biochemical interactions that are critical to this process are starting to emerge. The underlying principles of regional cell signaling and transcriptional control organizing early segmentation are the subject of this review.
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