YCM1008A, a novel Ca2+-Signaling inhibitor, produced by Fusarium sp YCM1008

In the course of screening for drugs that suppress the Ca2+-mediated growth inhibition in a yeast mutant, we found that the metabolite of Fusarium sp. strain YCM1008 inhibited Ca2+-signaling. A novel pyranopyridone, YCM1008A was isolated from the fermentation broth using HLB column chromatography followed by HPLC, and the structure was elucidated by spectral analysis. YCM1008A suppressed Ca2+-induced growth inhibition of the Saccharomyces cerevisiae (Delta zds1 Delta syr1) mutant.