期刊
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
卷 30, 期 7, 页码 RC13-RC16出版社
EDITRICE KURTIS S R L
DOI: 10.1007/BF03346344
关键词
leptin; adiponectin; insulin sensitivity
资金
- NCI NIH HHS [IU54CA116848-01] Funding Source: Medline
- NCRR NIH HHS [M01 RR00043] Funding Source: Medline
- NIA NIH HHS [5 T32 AG000093-24] Funding Source: Medline
- NIDDK NIH HHS [3R01DK59211-06S1, R01 DK59211] Funding Source: Medline
Because leptin and adiponectin are counter-regulated in vivo and exert opposing effects on glucose metabolism, fat oxidation and insulin sensitivity, the ratio of leptin-to-adiponectin has been investigated as a potential atherogenic index, suggesting that the index is a better biomarker for atherosclerotic risk in obese Type 2 diabetic patients than either leptin or adiponectin alone. However, no information is available regarding the leptin-to-adiponectin ratio during adolescence in Hispanic adolescents. Therefore, the present study was designed to investigate the leptin-to-adiponectin ratio during growth and to establish whether the leptin-to-adiponectin ratio is a better predictor for insulin sensitivity compared to leptin and adiponectin alone in a regression model. From the age of 8 to 14, the leptin-to-adiponectin ratio increased from 2.0 +/- 0.8 to 5.8 +/- 2.2 in girls, with no significant change noted in boys (gender x age interaction p=0.007). In a multiple regression analysis, including both adiponectin and leptin as independent variables, leptin and adiponectin explained 5% of the variation in insulin sensitivity independent of gender, age, Tanner stage, total fat mass and lean body mass (p for R-2-change <0.001). The leptin-to-adiponectin ratio also explained 5% of the variation in insulin sensitivity, after controlling for the same covariates (p for R-2-change <0.001). These data indicate that the leptin-to-adiponectin ratio is not a better predictor of insulin sensitivity during growth than the additive effects of leptin and adiponectin levels.
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