期刊
ANALYTICAL CHEMISTRY
卷 83, 期 6, 页码 2119-2124出版社
AMER CHEMICAL SOC
DOI: 10.1021/ac102932d
关键词
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资金
- National Institutes of Health [R01GM072512, 5K25EB6011-5]
- University of Maryland Center for Energetic Concepts Development (CECD)
- Defense Advanced Research Projects Agency (DARPA) [N66001-1-4003]
The wuse of porous polymer monoliths functionalized with silver nanoparticles is introduced in this work for high-sensitivity surface-enhanced Raman scattering (SERS) detection. Preparation of the SERS detection elements is a simple process comprising the synthesis of a discrete polymer monolith section within a silica capillary, followed by physically trapping silver nanoparticle aggregates within the monolith matrix. A SERS detection limit of 220 fmol for Rhodamine 6G is demonstrated, with excellent signal stability over a 24 h period. The capability of the SERS-active monolith for label-free detection of biomolecules was demonstrated by measurements of bradykinin and cyctochrome c. The SERS-active monoliths can be readily integrated into miniaturized micrototal-analysis systems for online and label-free detection for a variety of biosensing,, bioanalytical, and biomedical applications.
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