期刊
CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
卷 16, 期 4, 页码 311-318出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MNH.0b013e3281c55eca
关键词
aging; fibroblast growth factor 23; klotho; mineral ion homeostasis; vitamin D
资金
- NIDDK NIH HHS [R01 DK073944, R01 DK073944-03] Funding Source: Medline
Purpose of review The regulation of phosphate homeostasis was thought to be passively mediated by the calciotrophic hormones parathyroid hormone and 1,25(OH)(2)D-3. This article summarizes the emerging trends that show an active regulation of phosphate homeostasis by fibroblast growth factor 23 (FGF-23) - a process fairly independent of calcium homeostasis - and how altered mineral ion metabolism may affect the aging process: Recent findings A major breakthrough in FGF-23 biology has been achieved by the demonstration of strikingly similar physical/ biochemical phenotypes of Fgf-23(-/-) and klotho hypomorph mice, which eventually led to the identification of klotho as a cofactor in FGF-23 and its receptor interactions. Furthermore; FGF-23 has emerged as a counter regulator of the renal 1 alpha(OH)ase and sodium-phosphate cotransporter activities to modulate phosphate homeostasis. Finally, studies point towards a role of dentine matrix protein 1 in affecting phosphate homeostasis, in coordination with FGF-23: Summary Recent mouse genetic studies. have broadened our understanding of biochemical/molecular pathways involved in phosphate homeostasis; and linked FGF-23 to such regulation. Understanding the molecular interactions of essential calcium and phosphate regulators will enhance our knowledge of the coordinated regulation of mineral ion metabolism, and will help to redefine the molecular pathology of age-associated lesions accompanied by abnormal mineral ion metabolism such as vascular calcifications and osteoporosis.
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