期刊
DNA REPAIR
卷 6, 期 7, 页码 1042-1061出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.dnarep.2007.02.024
关键词
RFB; replication fork arrest; replication restart; RTS1
资金
- Medical Research Council [G0001129, G0600233] Funding Source: Medline
- MRC [G0001129, G0600233] Funding Source: UKRI
- Medical Research Council [G0001129, G0600233] Funding Source: researchfish
The arrest of DNA replication by DNA damage, nucleotide depletion, DNA-protein complexes or following clashes between transcription and replication factors all have the capacity to promote genome instability. In this review, we discuss how DNA replication is regulated by the checkpoint pathways that stabilise arrested replication forks and the recombination factors that process specific DNA structures resulting from fork arrest. We examine what is known about the interplay between the checkpoints and the recombination apparatus and review the evidence for a recombination-based fork restart pathway in eukaryotes. (C) 2007 Elsevier B.V. All rights reserved.
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