Intracellular amyloid-β in Alzheimer's disease

The primal role that the amyloid-beta(A beta) peptide has in the development of Alzheimer's disease is now almost universally accepted. It is also well recognized that A beta exists in multiple assembly states, which have different physiological or pathophysiological effects. Although the classical view is that A beta is deposited extracellularly, emerging evidence from transgenic mice and human patients indicates that this peptide can also accumulate intraneuronally, which may contribute to disease progression.