期刊
NATURE CLINICAL PRACTICE CARDIOVASCULAR MEDICINE
卷 4, 期 7, 页码 389-395出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ncpcardio0930
关键词
cardiovascular tissue engineering; CABG surgery; tissue-engineered blood vessel; tissue-engineered vascular graft; tissue engineering
There is a considerable clinical need for alternatives to the autologous vein and artery tissues used for vascular reconstructive surgeries such as CABG, lower limb bypass, arteriovenous shunts and repair of congenital defects to the pulmonary outflow tract. So far, synthetic materials have not matched the efficacy of native tissues, particularly in small diameter applications. The development of cardiovascular tissue engineering introduced the possibility of a living, biological graft that might mimic the functional properties of native vessels. While academic research in the field of tissue engineering in general has been active, as yet there has been no dear example of clinical and commercial success. The recent transition of cell-based therapies from experimental to clinical use has, however, reinvigorated the field of cardiovascular tissue engineering. Here, we discuss the most promising approaches specific to tissue-engineered blood vessels and briefly introduce our recent clinical results. The unique regulatory, reimbursement and production challenges facing personalized medicine are also discussed.
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