期刊
DNA REPAIR
卷 6, 期 7, 页码 891-899出版社
ELSEVIER
DOI: 10.1016/j.dnarep.2007.02.003
关键词
DNA polymerase; replication factories; PCNA; ubiquitination
资金
- MRC [G0501450] Funding Source: UKRI
- Medical Research Council [G0300662B, G0501450] Funding Source: researchfish
- Medical Research Council [G0501450] Funding Source: Medline
Replicative DNA polymerases are blocked at DNA lesions. Synthesis past DNA damage requires the replacement of the replicative polymerase by one of a group of specialised translesion synthesis (TLS) polymerases, most of which belong to the Y-family. Each of these has different substrate specificities for different types of damage. In eukaryotes mono-ubiquitination of PCNA plays a crucial role in the switch from replicative to TLS polymerases at stalled forks. All the Y-family polymerases have ubiquitin binding sites that increase their binding affinity for ubiquitinated PCNA at the sites of stalled forks. (C) 2007 Published by Elsevier B.V.
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