Amplified Protein Detection through Visible Plasmon Shifts in Gold Nanocrystal Solutions from Bacteriophage Platforms

A new method to engineer unique, solution-based protein diagnostics with femotomole sensitivies from modified bacteriophage is reported. These sensors are highly facile to use, rapid to run, possible to read without any spectroscopic or microscopic analysis, and do not require thermally unstable enzymes. These sensing platforms should be functional in locations with limited access to equipment and facilities.