期刊
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
卷 13, 期 7, 页码 838-843出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.bbmt.2007.03.007
关键词
parathyroid hormone; mobilization; stem cells
资金
- NHLBI NIH HHS [U54 HL081030] Funding Source: Medline
Autologous stem cell transplantation is a curative procedure for many patients with lymphomas, and has been shown to improve survival in patients with multiple myeloma. Approximately 20% of patients are unable to mobilize sufficient hematopoietic stem cells to proceed safely to autologous stem cell transplantation. Parathyroid hormone (PTH) affects osteoblasts and the stem cell niche, and has been shown to improve survival when given posttransplant in a mouse competitive transplant model. In this Phase I study, 20 subjects who had I or 2 unsuccessful stem cell mobilization attempts, received PTH in escalating doses of 40 jig, 60 mu g, 80 jig, and 100 mu g for 14 days. On days 10-14 of treatment, subjects received filgrastim 10 mu g/kg. The PTH was tolerated well and there was no dose-limiting toxicity. Forty-seven percent of subjects who had failed I prior mobilization attempt met the mobilization criteria of > 5 CD 34(+) cells/mu L in the peripheral blood. Forty percent of subjects who failed to reach adequate CD34(+) cell counts in 2 prior mobilization attempts met the mobilization criteria. PTH was well tolerated at doses up to 100 jig in human cancer patients. The efficacy of PTH for mobilization of hematopoietic stem cells will need to be tested in a larger Phase II study. (c) 2007 American Society for Blood and Marrow Transplantation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据