期刊
JOURNAL OF INFECTIOUS DISEASES
卷 196, 期 1, 页码 50-55出版社
OXFORD UNIV PRESS INC
DOI: 10.1086/518515
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资金
- NIAID NIH HHS [K08 AI51191-04] Funding Source: Medline
Elite suppressors maintain normal CD4(+) T cell counts and viral loads of < 50 copies of human immunodeficiency virus type 1 ( HIV-1) RNA per milliliter of plasma without antiviral therapy. We report here a case of virologic escape in a human leukocyte antigen ( HLA)-B(star)57-positive patient shortly after seroconversion. This escape was associated with the development of mutations in 2 HLA-B(star)57- restricted CD8(+) T cell Gag epitopes, reversion of the drug-resistance mutation M184V, and reversion of a novel polymorphism in Vpu. The present study suggests that control of viral replication in elite suppressors may be due to HIV-1-specific CD8(+) T cells and, in some cases, mutations that have subtle effects on viral fitness.
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