期刊
CLINICAL AND EXPERIMENTAL HYPERTENSION
卷 29, 期 5, 页码 287-299出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/10641960701500398
关键词
hypertension; spontaneously hypertensive rat; NAD(P)H oxidase; superoxide; nitric oxide; apocynin
The vascular NAD(P)H oxidase contributes to endothelial dysfunction and high blood pressure in the spontaneously hypertensive rat by enhancing superoxide production. We investigated the effects of apocynin, a NAD(P)H oxidase inhibitor on blood pressure and vascular radical and nitric oxide formation in SHR and compared its effects to the calcium channel blocker nifedipine. Apocynin (over four weeks) lowered systolic blood pressure significantly and as effectively as nifedipine. Both apocynin and nifedipine significantly reduced superoxide production. In parallel, vascular nitric oxide production and ecNOS activity was significantly increased by apocynin treatment. Therefore, apocynin may be an effective antihypertensive drug in essential hypertension.
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