期刊
ANALYTICAL CHEMISTRY
卷 82, 期 9, 页码 3707-3713出版社
AMER CHEMICAL SOC
DOI: 10.1021/ac100042e
关键词
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资金
- National Institute of General Medicine of the National Institutes of Health [R01 GM084366]
- Charles Stark Draper Laboratory
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM084366] Funding Source: NIH RePORTER
We have designed fluorescent nanosensors based on ion-selective optodes capable of detecting small molecules. By localizing the sensor components in a hydrophobic core, these nanosensors are able to monitor dynamic changes in concentration of the model analyte, glucose. The nanosensors demonstrated this response in vitro and also when injected subcutaneously into mice. The response of the nanosensors tracked changes in blood glucose levels in vivo that were comparable to measurements taken using a glucometer. The development of these nanosensors offers an alternative, minimally invasive tool for monitoring glucose levels in such fields as diabetes research. Furthermore, the extension of the ion-selective optode sensor platform to small molecule detection will allow for enhanced monitoring of physiological processes.
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