期刊
ANALYTICAL CHEMISTRY
卷 82, 期 23, 页码 9626-9630出版社
AMER CHEMICAL SOC
DOI: 10.1021/ac102475k
关键词
-
资金
- NSF
- National Institute for Biomedical Imaging and Bioengineering [5K25EB006011 5]
- Maryland Department of Business and Economic Development's (DBED) Nanobiotechnology Initiative
A novel, ultra low-cost surface enhanced Raman spectroscopy (SERS) substrate has been developed by modifying the surface chemistry of cellulose paper and patterning nanoparticle arrays, all with a consumer inkjet printer Micro/nanofabrication of SERS substrates for on-chip chemical and biomolecular analysis has been under intense investigation However, the high cost of producing these substrates and the limited shelf life severely limit their use, especially for routine laboratory analysis and for point-of-sample analysis in the field Paper-based microfluidic biosensing systems have shown great potential as low cost disposable analysis tools In this work, this concept is extended to SERS-based detection Using an inexpensive consumer inkjet printer, cellulose paper substrates are modified to be hydrophobic in the sensing regions Synthesized silver nanoparticles are printed onto this hydrophobic paper substrate with microscale precision to form sensing arrays The hydrophobic surface prevents the aqueous sample from spreading throughout the paper and thus concentrates the analyte within the sensing region A SERS fingerprint signal tor Rhodamine 6G dye was observed for samples with as low as 10 femtomoles of analyte in a total sample volume of 1 mu L This extraordinarily simple technique can be used to construct SERS microarrays immediately before sample analysis, enabling ultra low-cost chemical and biomolecular detection in the lab as well as in the field at the point of sample collection
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据