期刊
ANALYTICAL CHEMISTRY
卷 82, 期 11, 页码 4584-4590出版社
AMER CHEMICAL SOC
DOI: 10.1021/ac100594j
关键词
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资金
- Australian Research Council [DP0770619]
- Australian Research Council Discovery Linkage Infrastructure Equipment Facility (LIEF) [LE0668439]
- University of Sydney
Signature peptides of the neuraminidase antigen across all common circulating human subtypes of type A and B influenza are identified through the bioinformatic alignment of translated gene sequences. The detection of these peptides within the high-resolution mass spectra of whole antigen, virus, and vaccine digests enables the strains to be rapidly and directly typed and subtyped. Importantly, unique signature peptides for pandemic (H1N1) 2009 influenza are identified and detected that enable pandemic strains to be rapidly and directly differentiated from seasonal type A (H1N1) influenza strains. The detection of these peptides can enable the origins of the neuraminidase gene to be monitored in the case of reassorted strains.
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