期刊
VETERINARY JOURNAL
卷 174, 期 1, 页码 54-61出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.tvjl.2006.02.015
关键词
osteoarthritis; canine; glucosamine/chondroitin sulfate; clinical trial
Thirty-five dogs were included in a randomised, double-blind, positive controlled, multi-centre trial to assess the efficacy of an orally-administered glucosamine hydrochloride and chondroitin sulfate (Glu/CS) combination for the treatment of confirmed osteoarthritis of hips or elbows. Carprofen was used as a positive control. Dogs were re-examined on days 14, 42 and 70 after initiation of treatment. Medication was then withdrawn and dogs were re-assessed on day 98. Response to treatment was based on subjective evaluation by participating veterinarians who recorded their findings at each visit. Dogs treated with Glu/CS showed statistically significant improvements in scores for pain, weight-bearing and severity of the condition by day 70 (P < 0.001). Onset of significant response was slower for Glul CS than for carprofen-treated dogs. The results show that Glu/CS has a positive clinical effect in dogs with osteoarthritis. (c) 2006 Elsevier Ltd. All rights reserved.
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