期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 16, 期 4, 页码 7960-7975出版社
MDPI
DOI: 10.3390/ijms16047960
关键词
hydroxyapatite; waste eggshell; ibuprofen; drug delivery; supercritical loading
资金
- National Nature Science Foundation of China (NSFC) [21276212, 21476186]
The use of cheaper and recyclable biomaterials (like eggshells) to synthesize high purity hydroxyapatite (HAp) with better properties (small particle size, large surface area and pore volume) for applications (in environmental remediation, bone augmentation and replacement, and drug delivery systems) is vital since high-purity synthetic calcium sources are expensive. In this work, pure and mesoporous HAp nanopowder with large pore volume (1.4 cm(3)/g) and surface area (284.1 m(2)/g) was produced from raw eggshells at room temperature using a simple two-step procedure. The control of precursor droplets could stabilize the pH value of the reaction solution, because of the size of the needle (of the syringe pump used for precursor additions) leading to production of HAp with high surface area and pore size. The as-produced HAp revealed high ibuprofen (as a model drug) loading (1.38 g/g HAp), enhanced dissolution and controllable release of the drug via solute-saturated supercritical carbon dioxide.
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