期刊
ANALYTICAL CHEMISTRY
卷 82, 期 13, 页码 5887-5891出版社
AMER CHEMICAL SOC
DOI: 10.1021/ac902931x
关键词
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资金
- Japan Science and Technology Agency
- Ministry of Education, Culture, Sports, Science and Technology
We propose a novel strategy for determining the elemental composition of organic compounds using the peak ratio of isotopic fine structure observed by high-magnetic field Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR-MS). Using 3'-phosphoadenosine 5'-phosphosulfate and CTU guanamine as standard organic compounds, isotopic peaks derived from N-15-, S-34-, and O-18-substituted forms were separated from C-13-substituted species. Furthermore, these isotopic peaks were quantitatively detected and closely matched the natural abundance of each element. These data successfully led us to determine the one elemental composition in a standard independent manner. The approach should be particularly amenable to the metabolomics research field.
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