期刊
ANALYTICAL CHEMISTRY
卷 82, 期 11, 页码 4494-4500出版社
AMER CHEMICAL SOC
DOI: 10.1021/ac100390t
关键词
-
资金
- ETH
- Eidgenossische Stipendienkommission fur Auslandische Studierende (ESKAS)
- Swiss National Science Foundation (Switzerland) [200020-124663]
- Sino-Swiss Science and Technology Cooperation [IZLCZ2 123987]
- MOST (China) [2009 DFA41880]
Extractive electrospray ionization (EESI) is a powerful ambient ionization technique that can provide comprehensive mass spectrometric (MS) information on aerosols, complex liquids, or suspensions without any sample pretreatment. An understanding of the EESI mechanism is critical for defining its range of application, the advantages, and limitations of EESI, and for improving its repeatability, sensitivity, and selectivity. However, no systematic study of EESI mechanisms has been conducted so far. In this work, fluorescence studies in the EESI plume using rhodamine 6G and H-acid sodium salt directly demonstrate that liquid-phase interactions occur between charged ESI droplets and neutral sample droplets. Moreover, the effect of the composition of the primary ESI spray and sample spray on signals of the analyte in EESI-MS was investigated systematically. The results show that the analyte signals strongly depend on its solubility in the solvents involved, indicating that selective extraction is the dominant mechanism involved in the EESI process. This mechanistic study provides valuable insights for optimizing the performance of EESI in future applications.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据