期刊
DNA REPAIR
卷 6, 期 7, 页码 1018-1031出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.dnarep.2007.02.020
关键词
BRCA1; BRCA2; Rad51; sister chromatid recombination; daughter strand gap repair
资金
- NCI NIH HHS [CA95175, R01 CA095175, R01 CA095175-05] Funding Source: Medline
- NIGMS NIH HHS [GM073894, R01 GM073894-02, R01 GM073894] Funding Source: Medline
The hereditary breast and ovarian cancer predisposition genes, BRCA1 and BRCA2, participate in the repair of DNA double strand breaks by homologous recombination. Circumstantial evidence implicates these genes in recombinational responses to DNA polymerase stalling during the S phase of the cell cycle. These responses play a key role in preventing genomic instability and cancer. Here, we review the current literature implicating the BRCA pathway in HR at stalled replication forks and explore the hypothesis that BRCA1 and BRCA2 participate in the recombinational resolution of single stranded DNA lesions termed daughter strand gaps, generated during replication across a damaged DNA template. (C) 2007 Elsevier B.V. All rights reserved.
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