期刊
BIOPHYSICAL CHEMISTRY
卷 128, 期 2-3, 页码 231-244出版社
ELSEVIER
DOI: 10.1016/j.bpc.2007.04.009
关键词
microtubules; cytoskeleton; ordering; self-assembly; pattern formation; gravity
The dynamic behavior of microtubules in solution can be strongly modified by interactions with walls or other structures. We examine here a microtubule growth mode I where the increase in size of the plus-end is perturbed by collisions with other microtubules. We show that such a simple mechanism of constrained growth can induce ordered structures and patterns from an initially isotropic and homogeneous suspension. We find that microtubules self-organize locally in randomly oriented domains that grow and compete with each other. A weak orientation bias, similar to the one induced by gravity or cellular boundaries is enough to influence the domain growth direction, eventually leading to a macroscopic sample orientation. (c) 2007 Elsevier B.V. All rights reserved.
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