期刊
IMMUNITY
卷 27, 期 1, 页码 123-134出版社
CELL PRESS
DOI: 10.1016/j.immuni.2007.05.014
关键词
-
类别
资金
- NIAAA NIH HHS [AA02Z164] Funding Source: Medline
- NIAID NIH HHS [AI54696, AI41637] Funding Source: Medline
- NIGMS NIH HHS [GM67101] Funding Source: Medline
Dicer is essential for plant, Caenorhabditis elegans, and Drosophila antiviral responses because of its role in generating small interfering RNA (siRNA) from viral genomes. We show that because of impaired miRNA production, mice with a variant Dicer1 allele (Dicer1(d/d)) were more susceptible to vesicular stomatitis virus (VSV) infection. We did not detect VSV genome-derived siRNA in wild-type cells or any alteration of interferon-mediated antiviral responses by Dicer1 deficiency. Rather, we found that host miR24 and miR93 could target viral large protein (L protein) and phosphoprotein (P protein) genes, and a lack of miR24 and miR93 was responsible for increased VSV replication in Dicer1(d/d) cells. Our data suggest that host miRNA can play a role in host interactions with viruses.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据