期刊
HISTOPATHOLOGY
卷 51, 期 1, 页码 21-25出版社
WILEY
DOI: 10.1111/j.1365-2559.2007.02729.x
关键词
carcinoma expleomorphic adenoma; cyclin A; immunohistochemistry; pleomorphic adenoma; salivary gland tumour
Aims: To investigate cyclin A expression in pleomorphic adenoma (PA) and carcinoma expleomorphic adenoma (CXPA) of the parotid gland with a view to assessing its potential value as a diagnostic marker for CXPA. Methods and results: Cyclin A expression in PA and CXPA was studied using semiquantitiative immunohistochemistry. The epithelial component of the tumours expressed cyclin A in a statistically significantly (P < 0.005) higher number of CXPA cases (86%) compared with the PA cases (39%). Cyclin A was not expressed in normal salivary tissues of PA and CXPA. Conclusions: High cyclin A expression is a useful marker for the pathological diagnosis of CXPA.
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