期刊
AMERICAN JOURNAL OF HUMAN GENETICS
卷 81, 期 1, 页码 165-169出版社
CELL PRESS
DOI: 10.1086/518446
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资金
- NHGRI NIH HHS [R01 HG001645, R29 HG001645, HG1645] Funding Source: Medline
- NICHD NIH HHS [R01 HD021244, HD21244] Funding Source: Medline
Reproductive fitness is a complex phenotype that is a direct measure of Darwinian selection. Estimation of the genetic contribution to this phenotype in human populations is confounded by within-family correlations of sociocultural, economic, and other nongenetic factors that influence family sizes. Here, we report an intergenerational correlation in reproductive success in the Hutterites, a human population that is relatively homogeneous with respect to sociocultural factors that influence fertility. We introduce an estimator of this correlation that takes into account the presence of multiple parent-offspring pairs from the same nuclear family. Statistical significance of the estimated correlation is assessed by a permutation test that maintains the overall structure of the pedigree. Further, temporal trends in fertility within this population are accounted for. Applying these methods to the S- Leut Hutterites yields a correlation in effective family size of 0.29 between couples and their sons and 0.18 between couples and their daughters, with empirical P < 1 x and, respectively. Similar results were obtained for completed families (0.31 between couples and their 10(-6) and P = .0041 sons and 0.23 between couples and their daughters; empirical and, respectively). We interpret 56 P < 1 x 10(-6) P = .00059 these results as indicating a significant genetic component to reproductive fitness in the Hutterites.
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