期刊
ANALYTICAL CHEMISTRY
卷 81, 期 20, 页码 8447-8452出版社
AMER CHEMICAL SOC
DOI: 10.1021/ac901307q
关键词
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资金
- Gates Foundation
- California Institute of Technology Center for Optofluidic Integration
- DARPA [HR011-04-1-0032]
- MF3 Micro/Nano Fluidics Fundamentals Focus Center, NIH
- Eli Lilly
- Howard Hughes
- the Harvard-MIT Division of Health Science and Technology
- Ford Foundation
This article describes a point-of-care (POC) system-comprising a microfluidic, paper-based analytical device (mu-PAD) and a hand-held optical colorimeter-for quantifying the concentration of analytes in biological fluids. The mu-PAD runs colorimetric assays, and consists of paper that has been (i) patterned to expose isolated regions of hydrophilic zones and (ii) wet with an index-matching fluid (e.g., vegetable oil) that is applied using a disposable, plastic sleeve encasement. Measuring transmittance through paper represents a new method of quantitative detection that expands the potential functionality of mu-PADs. This prototype transmittance colorimeter is inexpensive, rugged, and fully self-contained, and thus potentially attractive for use in resource-limited environments and developing countries.
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