期刊
CYTOKINE & GROWTH FACTOR REVIEWS
卷 18, 期 3-4, 页码 287-298出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2007.04.008
关键词
GM-CSF; uterus; embryo; placenta; pregnancy
The reproductive tissues undergo profound structural changes and major immune adaptation to accommodate pregnancy. Granulocyte-macrophage colony-stimulating factor (GM-CSF) is one of an array of cytokines with pivotal roles in embryo implantation and subsequent development. Several cell lineages in the reproductive tract and gestational tissues synthesise GM-CSF under direction by ovarian steroid hormones and signalling agents originating in male seminal fluid and the conceptus. The pre-implantation embryo, invading placental trophoblast cells and the abundant populations of leukocytes controlling maternal immune tolerance are all subject to GM-CSF regulation. GM-CSF deficiency in pregnancy adversely impacts fetal and placental development, as well as progeny viability and growth after birth, highlighting this cytokine as a central maternal determinant of pregnancy outcome with clinical relevance in human fertility. (c) 2007 Elsevier Ltd. All rights reserved.
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