期刊
ACTA BIOMATERIALIA
卷 3, 期 4, 页码 449-455出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2006.12.001
关键词
hydrolytic degradation; ester hydrolysis rates; buffer pH; thiol-ene photopolymers
资金
- NIDCR NIH HHS [R01 DE12998, R01 DE012998, R01 DE012998-08] Funding Source: Medline
Networks synthesized through thiol-acrylate photopolymerization or Michael-type addition step growth reactions contain esters with neighboring sulfide groups. Previous work has demonstrated that these esters are readily hydrolyzable at physiological pH. Here, the influence of the distance between the sulfide and ester, as well as the water concentration, on ester hydrolysis was characterized. These preliminary results indicate that reducing the number of carbons between the sulfide and the ester from 2 to I increased the rate of ester hydrolysis from 0.022 +/- 0.001 to 0.08 +/- 0.015 days(-1). Increases in ester hydrolysis rates were also observed as hydrophilicity increased for oligomers prepared from a trithiol, tetrathiol and dithiol monomer (0.012 +/- 0.003, 0.032 +/- 0.004, and 0.091 +/- 0.003 days(-1), respectively). Additionally, in bulk-eroding polymeric biornaterials, variations in pH impacted the ester hydrolysis rate. This work confirms that small variations in buffer pH predictably alter the mass loss profile of a thiol-acrylate photopolymer. More specifically, as buffer pH was changed from 7.4 to 8.0, the rate of ester hydrolysis increased from 0.074 +/- 0.003 to 0.28 +/- 0.005 days(-1). The magnitude of this observed change in ester hydrolysis rate was correlated to the increase in hydroxide ion concentration that accompanied this pH change. (c) 2007 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
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