期刊
ANALYTICAL CHEMISTRY
卷 81, 期 24, 页码 9979-9984出版社
AMER CHEMICAL SOC
DOI: 10.1021/ac901744s
关键词
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资金
- Johns Hopkins Institute for Nanobiotechnology (INBT
- DuPont Young Professor Award
- NIH [1-DP2-OD004346-01]
Spatially resolved electrochemical recording of neurochemicals is difficult due to the challenges associated with producing manometer-scale patternable and integrated sensors. We describe the lithographic fabrication and characterization of patternable gold (Au) nanowire (NW) based sensors for the electrochemical recording of dopamine (DA). We demonstrate a straightforward NW-size-independent approach to align contact pads to NWs. Sensors, with NW widths as small as 30 nm, exhibited considerable insensitivity to scan rates during cyclic voltammetry, a nonlinear increase in oxidation current with increasing NW width, and the selectivity to measure submaximal synaptic concentrations of DA in the presence of interfering ascorbic acid. The electrochemical sensitivity of Au NW electrode sensors was much larger than that of Au thin-film electrodes. In chronoamperometric measurements, the NW sensors were found to be sensitive for submicromolar concentration of DA. Hence, the patternable NW sensors represent an attractive platform for electrochemical sensing and recording.
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