期刊
CELL HOST & MICROBE
卷 2, 期 1, 页码 55-67出版社
CELL PRESS
DOI: 10.1016/j.chom.2007.06.002
关键词
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资金
- NIGMS NIH HHS [R01 GM040266, R01 GM031318-44S1, R01 GM 31318, R01 GM035010-24, R01 GM035010, R01 GM040266-24, R01 GM 40266, R01 GM031318, R01 GM 35010] Funding Source: Medline
Innate immunity depends upon recognition of surface features common to broad groups of pathogens. The glucose polymer beta-glucan has been implicated in fungal immune recognition. Fungal walls have two kinds of beta-glucan: beta-1,3-glucan and beta-1,6-glucan. Predominance of beta-1,3-glucan has led to the presumption that it is the key immunological determinant for neutrophils. Examining various beta-glucans for their ability to stimulate human neutrophils, we find that the minor cell wall component beta-1,6-glucan mediates neutrophil activity more efficiently than beta-1,3-glucan, as measured by engulfment, production of reactive oxygen species, and expression of heat shock proteins. Neutrophils rapidly ingest beads coated with beta-1,6-glucan while ignoring those coated with beta-1,3-glucan. Complement factors C3b/C3d are deposited on beta-1,6-glucan more readily than on beta-1, 3-glucan. beta-1,6-glucan is also important for efficient engulfment of the human pathogen Candida albicans. These unique stimulatory effects offer potential for directed stimulation of neutrophils in a therapeutic context.
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