期刊
ANALYTICAL CHEMISTRY
卷 81, 期 16, 页码 6627-6632出版社
AMER CHEMICAL SOC
DOI: 10.1021/ac900551m
关键词
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资金
- DuPont Young Professor Award
- Hong Kong UGC [DAG07/08.SC01, WMINST08/09.SC02]
This report describes a convenient and reproducible method for the covalent modification of poly(dimethylsiloxane) (PDMS) with poly(ethylene glycol) (PEG) chains to suppress nonspecific protein adsorption. PEG additives terminated with a vinyl group are added into the PDMS prepolymer; when the PDMS is thermally cured, the vinyl group reacts with the silane groups on the PDMS, which covalently link the PEG group to the PDMS network. The PEG-modified PDMS surfaces are characterized with FT-IR, X-ray photoelectron spectroscopy (XPS), and contact angle measurement. We also examined the modified PDMS for on-chip capillary electrophoresis and its capability of resisting nonspecific protein adsorption using bovine serum albumin (BSA) as a model. Based on our study, a molecular mechanism is given to successfully explain the surface properties of the modified PDMS surfaces.
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