期刊
NEUROCHEMISTRY INTERNATIONAL
卷 51, 期 2-4, 页码 105-111出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuint.2007.05.007
关键词
UCH-L1; ubiquitin; Parkinson's disease; Alzheimer's disease; gad mouse; oxidative stress; mono-ubiquitination
Parkinson's disease (PD) and Alzheimer's disease (AD), the most common neurodegenerative diseases, are caused by both genetic and environmental factors. Ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) is a deubiquitinating enzyme that is involved in the pathogenesis of both of these neurodegenerative diseases. Several functions of UCH-L1, other than as an ubiquitin hydrolase, have been proposed; these include acting as an ubiquitin ligase and stabilizing mono-ubiquitin. This review focuses on recent findings on the functions and the regulation of UCH-L1, in particular those that relate to PD and AD. (c) 2007 Elsevier Ltd. All rights reserved.
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