期刊
JOURNAL OF VIROLOGY
卷 81, 期 14, 页码 7805-7810出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.02388-06
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Enhancers are defined as DNA elements that increase transcription when placed in any orientation relative to a promoter. The major immediate-early (MIE) enhancer region of murine cytomegalovirus is flanked by transcription units ie]13 and ie2, which are transcribed in opposite directions. We have addressed the fundamental mechanistic question of whether the enhancer synchronizes transcription of the bidirectional gene pair (synchronizer model) or whether it operates as a genetic switch, enhancing transcription of either gene in a stochastic alternation (switch model). Clonal analysis of cytokinetriggered, transcription factor-mediated MIE gene expression from latent viral genomes provided evidence in support of the switch model.
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