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JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
卷 205, 期 1, 页码 52-59出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jamcollsurg.2007.02.077
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Background: Although malnutrition was found to increase the risk of intraabdominal and systemic complications in surgical patients, data for distal pancreatic resections are scarce. Study Design: Data on 132 consecutive patients undergoing distal pancreatectomy as the primary procedure for pancreatic pathology, between 1996 and 2005, were reviewed to identify risk factors for postoperative complications and determine the impact of nutritional status. Nutritional assessment was performed with clinical and laboratory variables, including unintentional weight loss, body mass index, blood albumin level, lyrnphocyte count, and Nutritional Risk Index (NRI) and Instant Nutritional Assessment (INA) scores. Results: Seventy-five (56.8%) patients developed 1 or more complications, including 18 (13.6%) cases of pancreatic fistula. The median values of NRI were significantly lower in patients with pancreatic fistula (96.9; 95% CI, 89.8 to 101.0) compared with those in the remaining subjects (102.5; 95% CI, 101.5 to 105.5; p=0.014). In the univariate analysis, the incidence of malnutrition defined by NRI (61% versus 30%, p=0.019) and the Instant Nutritional Assessment (67% versus 34%, p=0.017) was significantly higher in patients who developed pancreatic fistula. In the multivariate analysis, malnutrition characterized as NRI of 100 or less was the only factor that significantly increased the risk of pancreatic fistula, with an odds ratio of 8.12 (95% CI, 1.06 to 22.30). Conclusions: Malnutrition, as defined by composite nutritional assessment scales consisting of clinical and laboratory parameters, is a major risk factor for pancreatic fistula after distal pancreatectomy.
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